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Polynucleotides · Simple Routine · Pacific Plaza

Rejuran Aftercare —
A Simple Routine While It Settles

Atelier Aesthetics · Medical Director: Dr. Sin Yong · Updated 25 Oct 2026

Rejuran is placed as many fine deposits across the treated area, so you leave with an even pattern of small raised papules rather than a few bumps. Aftercare keeps your routine plain and your hands away while they settle; where your written sheet from Dr Sin Yong differs, follow the sheet.

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Day One

1. The First 24 Hours

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The area looks evenly dotted and pink, and it may stay numb for a while from the topical anaesthetic applied beforehand. The product is a salmon-derived polynucleotide (PDRN); how it works is on Rejuran at Atelier.

Do

  • Cleanse that evening with your fingertips only, using lukewarm water and a mild, non-foaming cleanser, and pat the skin dry.
  • Once the skin is dry, a plain moisturiser is fine.
  • Rest a cool compress on a tender spot for a short spell, without pressing.
  • Put a fresh pillowcase on before bed, and sleep face-up with your head a little raised.
  • Keep your hands away from your face.

Avoid

  • Pressing, rubbing or massaging the papules, or picking at any crust.
  • Make-up until the entry points have closed.
  • Hot showers on the face, saunas, steam, hot yoga, alcohol and vigorous exercise, because heat prolongs the redness.
  • Facials and at-home devices.

While It Settles

2. The First Week

How the papules and any bruising fade, and when you can be seen, is on Rejuran downtime.

Facials, facial massage, gua sha, microneedling and home devices over the area wait until your skin is back to normal, and laser or radiofrequency keeps to the spacing in your plan.

Skin And Sun

3. Skincare And Sun Protection

Leave scrubs, exfoliating acids, retinoids and vitamin C serums aside until the papules have gone and your skin feels normal. Then bring active products back one at a time, and save anything new for later.

Once the entry points have closed, apply a broad-spectrum sunscreen each morning and again when you are outdoors. Keep bruises covered or under sunscreen, since sun can leave a brown mark in skin types III to V, and avoid deliberate tanning.

Everyday Life

4. Activity, Heat And Make-Up

Exercise and heat. Walking is fine after the first day. Vigorous exercise, hot classes, saunas, steam and alcohol wait at least 24–48 hours, and until the papules have settled and any bruising has stopped spreading.

Make-up. When the entry points have closed, use it lightly over intact skin and take it off without rubbing. A light concealer hides a bruise better than foundation applied with a brush.

Safety

5. When To Contact The Clinic

Settling papules, redness, mild swelling, tenderness and bruising, especially around the eyes, clear on their own. These need the clinic.

Contact the clinic straight away

  • skin near a point turning white, dusky, purple or net-like;
  • pain that is severe and getting worse.

Call or WhatsApp +65 8023 7170 at once. If you cannot reach the clinic, or it is outside clinic hours (Monday to Saturday, 11:00–20:00), go to the nearest hospital emergency department.

Message the clinic the same day

  • pain that is increasing;
  • redness spreading with warmth, or pus at an entry point;
  • swelling that does not go down, or clearly grows after the first day;
  • a lump that persists or grows: uneven or shallow deposits can form nodules, which are examined, not massaged;
  • itching, hives, or swelling that spreads beyond the treated area.

WhatsApp a photo of the area.

Go to the nearest hospital emergency department now

  • swelling of the lips, tongue or throat with difficulty breathing;
  • any change in your vision.

Go without waiting for a reply, and call 995 if needed. If you were treated elsewhere, bring the product name, the areas and the date. More on complication care.

WhatsApp the clinic: +65 8023 7170

FAQ

Rejuran Aftercare — Common Questions

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No, only while each set of papules settles. The course is usually three to four sessions, two to four weeks apart, and between them your usual routine returns once the papules have gone and your skin feels normal. Bring actives back one at a time, and keep the broad-spectrum sunscreen going every day throughout the course.
Not straight away. Chlorinated pools wait until the entry points have closed, and waxing or threading near the treated area waits until the papules have gone. If the area around the eyes was treated, contact lenses can go back in once any swelling has settled, while eye make-up waits until the skin there looks normal again.
Tell the clinic before treatment. Rejuran is salmon-derived, so a fish or seafood allergy is discussed and documented first. Allergic reactions are rare. After any session, itching, hives or swelling that spreads beyond the treated area needs to be seen the same day. If the lips, tongue or throat swell, or breathing becomes difficult, treat it as an emergency and go to the nearest hospital emergency department.
It is one of the simple hygiene steps for the first night, along with keeping your hands off your face, while the many small entry points are still open. Infection after Rejuran is uncommon, but it is possible. Increasing pain, redness spreading with warmth, or pus at an entry point is a reason to message the clinic that day.

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Related at Atelier

Related
Rejuran — PDRN Renewal
Salmon-derived polynucleotides for repair and inflammation, in a course of three to four sessions.
Related
Rejuran Downtime
How the dotted injection marks look and fade, and when you can be seen.
Related
Skin Booster Aftercare
How aftercare differs between Profhilo, Rejuran and PDLLA.

References

  1. Pak CS, et al. Polynucleotide vs hyaluronic acid filler for crow's feet: a phase III randomised comparison. J Korean Med Sci, 2014. PMID 25473210.
  2. Choi SY, et al. Polycaprolactone and polynucleotide fillers for crow's feet. J Cosmet Dermatol, 2025. PMID 39313949.
  3. Kim TH, et al. Polydeoxyribonucleotide from marine organisms in biomedical engineering. Mar Drugs, 2021. PMID 34067499.
  4. Ministry of Health, Singapore
  5. HealthHub, Singapore — public health information

More on this topic

Atelier Aesthetics · Owned by AYA

Keep it simple —
let the papules settle.

9 Scotts Road, Pacific Plaza #12-01A, Singapore 228210 · +65 8023 7170

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